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Microbiology and biocatalysis for industry


Program (detailed contents):

Microbial physiology

Physiological behavior for industrial production (starter, proteins, polysaccharides, amino acids, antibiotics,...)

- Cell energetics and constraints for industrial implementation


- Modelling strategy for the microbial reaction

- Phenomenological models

- Metabolic flux models

- Structured models

Behavior of high cell density bioreactor

continuous culture reactors, recycled cell reactors

- Fed-batch reactors

Bioreactor control

- Fed-batch control for limiting conditions

- Optimization strategy for no limiting conditions

Distillation - heat exchange - chemical and biological reactors


New ways of modifying properties of biocatalysts

Use of enzymes in industry

Bioseparation techniques for proteins



- projects

- Lab work


At the end of this module, the student will have understood and be able to explain (main concepts) :


- High cell density microbial cultures for industrial production, integrating the physiological constraints

- Modelling the biological reaction

- Controlling the fermentation process

- The design of an industrial process

- Applied enzyme catalysis


The student will be able to:


- design and simulate models describing the microbial productions

- design and implement microbial cultures for high performance reactors

- apply enzyme engineering techniques

Needed prerequisite

Structural and metabolic biochemistry - Microbiology - Microbiological engineering -Bioreactor engineering

Form of assessment

The evaluation of outcome prior learning is made as a continuous training during the semester. According ot the teaching, the assessment will be different: as a written exam, an oral exam, a record, a written report, peers review...