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Organic Chemistry


Programme (detailed contents):


Part 1: Spatial and electronic structures
- Hybridization of atomic orbitals and geometry of organic molecules.

- Nomenclature.
- Constitutional and conformational isomerism.

- Stereoisomerism (enantiomers, diastereoisomers…)
- Electronic effects: polarity, polarisability, inductive and mesomeric effects.
- Structure-reactivity relationship: large classes of reagents: acids, bases, nucleophiles, electrophiles, the reaction intermediates: carbocations, carbanions, free radicals.

Part II: Reactivity of compounds. The major reaction mechanisms.

- Radical substitutions (RH).
- Electrophilic additions to alkenes (EI).
- Aromatic electrophilic substitution (SE).
- Aliphatic nucleophilic substitutions (SN1 and SN2).
- Eliminations (E1 and E2).
- Reactivity of carbonyl compounds: nucleophilic addition, acidity of alpha hydrogens.

Basic practical course:
- Resolution of a racemic mixture.
- Chemical Synthesis.
Develop, implement the main experimental techniques (distillation, extraction, reflux, recrystallization, chromatography ..).
- Educate students to safety during handling in chemistry.



Experimental project:
The students must work in groups on a proposed chemical synthesis. Find information, propose a procedure by incorporating the cost of handling and the risks encountered, plan and implement the protocol.

Organization (running):
Lectures/ Tutorials for the acquisition of knowledge in chemistry.


At the end of this module, the student will have understood and be able to explain (main concepts):
- Spatial and electronic structures of molecules to understand the main reaction
mechanisms and stereochemical consequences.
- Basic reaction mechanisms of chemical reactions of life and industrial organic
The student will be able to:
- Identify key functions and namie chemical compounds.
- Represent the chemical compounds (Newman, Fischer, Cram¿)
- Distinguish the different types of stereo-isomerism: conformational isomerism,
enantiomers, diastereomers, E/Z isomerism... - Analyse the electronic effects
(inductive and mesomeric effects) in a molecule. - Describe the different
classes of reagents and reactive intermediates. - Describe the main reaction
mechanisms encountered in chemistry: radical substitutions on alkanes (SR),
electrophilic additions to alkenes (EI), aromatic electrophilic substitutions (SE),
aliphatic nucleophilic substitutions (SN1 and SN2), elimination (E1 and E2), Reactivity
of carbonyl compounds: nucleophilic addition, acidity of alpha hydrogens.
- Synthesize organic compounds implementing the basic experimental techniques of organic

Needed prerequisite

Chemical bonding / Solution chemistry

Form of assessment

The evaluation of outcome prior learning is made as a continuous training during the semester. According ot the teaching, the assessment will be different: as a written exam, an oral exam, a record, a written report, peers review...

Additional information

Stereochemistry, electronic effects: mesomeric and inductive effects, reaction mechanisms, radical substitution, aliphatic nucleophilic substitution, aromatic electrophilic substitution, electrophilic addition, elimination, nucleophilic addition.


I1ANBC40 Chemical bonding

I1ANCH10 Solution chemistry